Chimeric Peptide Tat-HA-NR2B9c Improves Regenerative Repair after Transient Global Ischemia
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چکیده
منابع مشابه
Chimeric Peptide Tat-HA-NR2B9c Improves Regenerative Repair after Transient Global Ischemia
Transient global ischemia (TGI) is a major public health problem, and it heightens the need of effective treatments. The present study was undertaken to investigate whether recombinant polypeptide Tat-HA-NR2B9c improves spatial learning and memory deficits in rats after TGI. Rats were subjected to 20-min ischemia induced by four-vessel occlusion (4-VO) method and daily injected with Tat-HA-NR2B...
متن کامل“Delayed Administration of Tat-HA-NR2B9c Promotes Recovery After Stroke in Rats”
We thank Drs Zuo and Xu for their interesting letter pertaining to our recently published article, “Delayed administration of Tat-HA-NR2B9c promotes recovery after stroke in rats.” We would like to take this opportunity to formally address Drs Zuo and Xu’s letter. Cyclin-dependent kinase 5 (Cdk5) is a multifaceted serine/ threonine kinase protein. The 35-kDa regulatory activator (p35) of cdk5 i...
متن کاملResponse to Letter Regarding Article, "Delayed Administration of Tat-HA-NR2B9c Promotes Recovery After Stroke in Rats".
BACKGROUND AND PURPOSE Previous studies reported that Tat-NR2B9c, a peptide disrupting the N-methyl-d-aspartate receptor-postsynaptic density protein-95 interaction, reduced ischemic damage in the acute phase after stroke. However, its effect in the subacute phase is unknown. The aim of this study is to determine whether disrupting the N-methyl-d-aspartate receptor-postsynaptic density protein-...
متن کاملLetter by Zuo and Xu Regarding Article, "Delayed Administration of Tat-HA-NR2B9c Promotes Recovery After Stroke in Rats".
Letter by Zuo and Xu Regarding Article, “Delayed Administration of Tat-HA-NR2B9c Promotes Recovery After Stroke in Rats” To the Editor: We read with interest the recent study by Zhou et al titled “Delayed Administration of Tat-HA-NR2B9c Promotes Recovery After Stroke in Rats.” The authors performed a study to investigate a potential role and mechanism of Tat-HA-NR2B9c in the subacute phase afte...
متن کاملTat-NR2B9c prevents excitotoxic neuronal superoxide production.
The Tat-NR2B9c peptide has shown clinical efficacy as a neuroprotective agent in acute stroke. Tat-NR2B9c is designed to prevent nitric oxide (NO) production by preventing postsynaptic density protein 95 (PSD-95) binding to N-methyl-D-aspartate (NMDA) receptors and neuronal nitric oxide synthase; however, PSD-95 is a scaffolding protein that also couples NMDA receptors to other downstream effec...
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ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2017
ISSN: 1664-2295
DOI: 10.3389/fneur.2017.00509